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The sperm activates the egg to begin developing into an embryo by triggering a wave of intracellular calcium release, which sweeps across the egg like a forest fire. The identity of the signaling molecules that mediate this fundamental event has remained a mystery until recently. Now, new information emerging from the genome projects has made it possible to isolate and characterize the proteins responsible.

Type

Journal article

Journal

Biologist (London)

Publication Date

02/2003

Volume

50

Pages

5 - 10

Keywords

Animals, Calcium Signaling, Female, Fertilization, Fertilization in Vitro, Humans, Male, Ovum, Parthenogenesis, Sperm-Ovum Interactions, Spermatozoa