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UNLABELLED: We report significant and controlled cell death using novel x-ray-activatable titania nanoparticles (NPs) doped with lanthanides. Preferential incorporation of such materials into tumor tissue can enhance the effect of radiation therapy. Herein, the incorporation of gadolinium into the NPs is designed to optimize localized energy absorption from a conventional medical x-ray. This result is further optimized by the addition of other rare earth elements. Upon irradiation, energy is transferred to the titania crystal structure, resulting in the generation of reactive oxygen species (ROS). FROM THE CLINICAL EDITOR: The authors report significant and controlled cell death using x-ray-activated titania nanoparticles doped with lanthanides as enhancers. Upon irradiation X-ray energy is transferred to the titania crystal structure, resulting in the generation of reactive oxygen species.

Original publication

DOI

10.1016/j.nano.2011.08.003

Type

Journal article

Journal

Nanomedicine

Publication Date

05/2012

Volume

8

Pages

526 - 536

Keywords

Adolescent, Cell Line, Cell Proliferation, Child, Female, Humans, Lanthanoid Series Elements, Male, Metal Nanoparticles, Neoplasms, Radiation-Sensitizing Agents, Reactive Oxygen Species, Titanium, X-Ray Therapy