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AIM: This paper describes the treatment and survival of 1576 children with retinoblastoma in Great Britain diagnosed 1963-2002. METHODS: Survival rates were analysed according to period of diagnosis and tumour laterality. RESULTS: Survival was calculated by calendar period of diagnosis, 1963-1982 and 1983-2002. For both unilateral and bilateral retinoblastoma, survival improved between the two periods. The survival curves for the two periods were significantly different: for unilateral retinoblastoma p<0.00001, for bilateral p<0.01. For unilateral cases, the estimated 5-year survival rates rose from 85% for those diagnosed in 1963-1967 to 97% for those diagnosed in 1998-2002. The equivalent rates for bilateral cases were 88% and 100%. CONCLUSION: Survival rates were already high at the start of the study period. They increased with changes in treatment regimens.

Original publication




Journal article


Br J Ophthalmol

Publication Date





38 - 39


Adolescent, Antineoplastic Combined Chemotherapy Protocols, Child, Child, Preschool, Eye Enucleation, Female, Great Britain, Humans, Infant, Infant, Newborn, Male, Registries, Retinal Neoplasms, Retinoblastoma, Survival Analysis, Survival Rate