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BACKGROUND: Wilms tumour is an embryonal malignant tumour that accounts for 90% of childhood kidney cancers. Parental occupational exposure has been hypothesised to be a cause of childhood Wilms tumour, in particular exposure to pesticides. However, the findings are inconsistent. PROCEDURE: We have examined the association between paternal occupational exposures and Wilms tumour using birth registration data for cases (n = 2568) from the National Registry of Childhood Tumours (NRCT) and matched controls (n = 2,568) drawn from the general population of Great Britain. Paternal occupation, as recorded at the time of birth, was used to infer "occupational exposure" using a previously defined occupational exposure classification scheme. Odds ratios and 95% confidence intervals were generated using conditional logistic regression with exact methods to estimate the association between each paternal occupational exposure group and childhood Wilms tumour. RESULTS: All odds ratios were close to 1.00 and no statistically significant associations were observed. CONCLUSION: The results of this study failed to support any of the previously identified associations between paternal occupation and childhood Wilms tumour.

Original publication

DOI

10.1002/pbc.22013

Type

Journal article

Journal

Pediatr Blood Cancer

Publication Date

07/2009

Volume

53

Pages

28 - 32

Keywords

Adult, Female, Humans, Infant, Newborn, Kidney Neoplasms, Male, Occupational Exposure, Occupations, Odds Ratio, Paternal Exposure, Pregnancy, Prenatal Exposure Delayed Effects, Registries, Risk Assessment, Social Class, United Kingdom, Wilms Tumor