Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The renin-angiotensin system not only plays a critical role in blood pressure control but is also involved in learning and memory mechanisms. In addition to angiotensin (Ang) II, Ang-(1-7) may also have important biological activities in the brain. Here, we show for the first time that Ang-(1-7) enhances long-term potentiation (LTP) in the CA1 region of the hippocampus. Our studies with AT1 receptor antagonists and selective Ang-(1-7) receptor antagonists demonstrate the existence of a distinct Ang-(1-7) receptor in the brain, the G-protein-coupled receptor Mas, encoded by the Mas protooncogene. We also show that the genetic deletion of this receptor abolishes the Ang-(1-7)-induced enhancement of LTP. Thus, we firstly demonstrate that Ang-(1-7) influences the induction of LTP in limbic structures implicating its distinct function in learning and memory mechanisms; secondly, we have identified Mas as a functional receptor for Ang-(1-7) in the brain.

Original publication

DOI

10.1016/j.mcn.2005.03.012

Type

Journal article

Journal

Mol Cell Neurosci

Publication Date

07/2005

Volume

29

Pages

427 - 435

Keywords

Angiotensin I, Angiotensin II Type 1 Receptor Blockers, Animals, Dose-Response Relationship, Drug, Electric Stimulation, Enzyme Inhibitors, Hippocampus, Learning, Long-Term Potentiation, Male, Memory, Mice, Mice, Knockout, Neurons, Organ Culture Techniques, Peptide Fragments, Proto-Oncogene Proteins, Receptor, Angiotensin, Type 1, Receptors, G-Protein-Coupled, Up-Regulation