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Chromosome abnormalities are common among human oocytes and are usually lethal to any embryos they produce. It therefore seems logical that a reliable technique for distinguishing between normal and aneuploid embryos would be a useful tool for physicians and embryologists, assisting the choice of which embryo(s) to prioritize for uterine transfer. This concept has led to the development of a variety of methods for the detection of chromosome abnormalities in oocytes and embryos, most often referred to as preimplantation genetic screening (PGS). However, several well-controlled studies have been unable to show an advantage of chromosome screening in terms of pregnancy and birth rates. Some investigators have suggested that damage to embryos, sustained during cleavage-stage biopsy, might explain why PGS has not always provided the anticipated benefits. This paper asks whether there is evidence that a non-invasive, morphological analysis could allow chromosomally normal embryos to be accurately identified and reviews data from the most recent publication concerning IVF outcome following PGS.

Original publication

DOI

10.1016/j.rbmo.2010.06.035

Type

Journal article

Journal

Reprod Biomed Online

Publication Date

09/2010

Volume

21

Pages

274 - 277

Keywords

Aneuploidy, Blastocyst, Embryo Transfer, Female, Fertilization in Vitro, Genetic Testing, Humans, Infant, Newborn, Pregnancy, Pregnancy Outcome, Preimplantation Diagnosis