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Pre-eclampsia (P-EC), a heterogenic multisystem disorder characterized by hypertension and proteinuria, usually develops in the second half of pregnancy. The incidence is 2 to 5%, and P-EC is therefore a major cause of maternal and perinatal morbidity and mortality. Although the exact etiology is unknown, placental factors released into the maternal circulation lead to systemic maternal inflammation and endothelial dysfunction. Growing evidence indicates that placenta-derived microparticles, best known as syncytiotrophoblast microparticles (STBM), are important among these factors. This review provides an overview of the presence and function(s) of STBM and other cell-derived microparticles and exosomes.

Original publication

DOI

10.1055/s-0030-1270342

Type

Journal article

Journal

Semin Thromb Hemost

Publication Date

03/2011

Volume

37

Pages

146 - 152

Keywords

Blood Coagulation, Cell-Derived Microparticles, Exosomes, Female, Humans, Inflammation, Inflammation Mediators, Placenta, Pre-Eclampsia, Pregnancy, Trophoblasts, Vasodilation