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OBJECTIVE: To determine the extent of intra-age and intercycle variations in the frequency of first polar body aneuploidy in two consecutive cycles of oocyte retrieval undertaken by the same patient within 1 year. DESIGN: Retrospective study. SETTING: Fertility centers. PATIENT(S): Infertile couples undergoing IVF. INTERVENTION(S): Patients underwent two consecutive cycles of preimplantation genetic screening through first polar body biopsy within 1 year. MAIN OUTCOME MEASURE(S): Meiosis I aneuploidy. RESULT(S): A total of 226 patients underwent 452 cycles of preimplantation genetic screening. Differences within age groups were wide, with 0-100% of oocytes being chromosomally normal in all age groups. Euploidy rates between centers were significantly different (48% vs. 25%). Intercycle differences for the same patient were also wide (0-100%), but with 68.5% of patients having less than ±2 euploid eggs of difference between cycles. CONCLUSION(S): Although euploidy rate decreased on average with advancing maternal age, the high intra-age and intercenter variation in oocyte chromosome abnormalities emphasize the difficulty in estimating how many euploid oocytes a specific woman will have. This may have repercussions for fertility preservation where a defined number of eggs are currently frozen just based on maternal age.

Original publication

DOI

10.1016/j.fertnstert.2012.01.106

Type

Journal article

Journal

Fertil Steril

Publication Date

04/2012

Volume

97

Pages

935 - 942

Keywords

Adult, Age Factors, Aneuploidy, Biopsy, Chromosome Aberrations, Chromosomes, Human, Cryopreservation, Female, Fertility Agents, Female, Genetic Testing, Germany, Health Facilities, Humans, In Situ Hybridization, Fluorescence, Infertility, Italy, Linear Models, Meiosis, Middle Aged, Oocytes, Ovulation, Ovulation Induction, Polar Bodies, Preimplantation Diagnosis, Retrospective Studies, Risk Assessment, Risk Factors, Time Factors