Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

While the role of C2-ceramide in the induction of programmed cell death (PCD) in animal systems has been well documented, little is known of its role in plant cells. Here we show that C2-ceramide induces PCD in Arabidopsis suspension cultures, which is preceded by the generation of a calcium transient and an increase in reactive oxygen species (ROS). Inhibition of the calcium transient prevented cell death, whereas inhibition of ROS had no effect on cell survival. These observations suggest that calcium signalling plays a role in ceramide-induced PCD but is independent of the generation of ROS.

Original publication

DOI

10.1515/BC.2005.020

Type

Journal article

Journal

Biol Chem

Publication Date

02/2005

Volume

386

Pages

161 - 166

Keywords

Apoptosis, Arabidopsis, Calcium, Calcium Signaling, Cells, Cultured, Ceramides, In Situ Nick-End Labeling, Reactive Oxygen Species, Sphingosine