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OBJECTIVE: We investigated a possible association between endometriosis and polymorphisms in the genes encoding epidermal growth factor (EGF) receptor (EGFR) and EGF in a Japanese population. METHODS: We compared the distribution of the Egfr+2073 A/T and Egf+61 G/A polymorphisms by polymerase chain reaction-restriction fragment length polymorphism analysis in 146 affected women and 181 controls. RESULTS: No significant differences in the frequency and genotype distribution of the Egfr+2073 A/T and Egf+61 G/A polymorphisms were found between endometriosis patients with all disease stages and controls. Stratification by disease stage had no effect on the results. CONCLUSION: The Egfr+2073 A/T and Egf+61 G/A polymorphisms are not associated with an increased risk of endometriosis in a Japanese population.

Original publication




Journal article


Gynecol Endocrinol

Publication Date





474 - 478


Adult, Amplified Fragment Length Polymorphism Analysis, Asian Continental Ancestry Group, Chi-Square Distribution, Endometriosis, Epidermal Growth Factor, Female, Gene Frequency, Genetic Association Studies, Genetic Predisposition to Disease, Humans, Infant, Newborn, Japan, Odds Ratio, Polymorphism, Restriction Fragment Length, Receptor, Epidermal Growth Factor, Severity of Illness Index