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OBJECTIVE: To investigate the association of the -174 G/C promoter polymorphism of the interleukin-6 (IL-6) gene with endometriosis in South Indian women. METHODS: The genotype frequencies of the common IL-6 -174 G/C polymorphism were compared in infertility patients with (n = 232) and without (n = 210) endometriosis using polymerase chain reaction (PCR) and sequencing analysis. RESULTS: The genotype frequencies among the cases and controls were G/G 62.9% and 71.9%, G/C 34.1% and 25.2%, and C/C 3.0% and 2.9%. The G and C allele frequencies were 80% and 84.6%, and 20% and 15.4%, respectively. There were no statistically significant differences in the genotype distributions or allele frequencies between the cases and controls (P = .12). CONCLUSIONS: The present study demonstrates no significant association between the IL-6 -174 G/C promoter polymorphism and endometriosis in South Indian women.

Original publication

DOI

10.1016/j.jsgi.2005.03.005

Type

Journal article

Journal

J Soc Gynecol Investig

Publication Date

07/2005

Volume

12

Pages

365 - 369

Keywords

Adult, Case-Control Studies, Endometriosis, Female, Genotype, Humans, India, Interleukin-6, Polymerase Chain Reaction, Polymorphism, Genetic, Promoter Regions, Genetic, Risk Factors