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The global distribution of HIV-1 subtypes and recombinants is extremely complex and dynamic. The increasing diversity has profound implications for many aspects of the pandemic, including viral pathogenicity, transmission, diagnosis, treatment, and vaccine development. HIV-1 genetic diversity surveillance is crucial in tackling the pandemic, but systematic surveillance at national, regional, and global levels has, to date, been lacking. Here, we discuss methods for gathering representative HIV-1 molecular epidemiology data and incorporating these into a comprehensive global HIV-1 diversity monitoring system.

Original publication

DOI

10.1016/j.molmed.2012.06.004

Type

Journal article

Journal

Trends Mol Med

Publication Date

12/2012

Volume

18

Pages

691 - 694

Keywords

Databases, Genetic, Epidemiological Monitoring, Genetic Variation, Global Health, HIV-1, Molecular Epidemiology