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OBJECTIVE: To examine the effects of diabetes on coronary heart disease, ischemic and hemorrhagic stroke and cardiovascular disease according to category of body mass index. METHODS: Data on 161,161 men and women from 31 cohorts (baseline years, 1966-99; mean follow-up, 2-24 years) from the Asia Pacific Cohort Studies Collaboration were analyzed using Cox regression, stratified by sex and study and adjusted for age, systolic blood pressure and smoking. Diabetes was self-reported in all but one study. Body mass index was divided into five categories according to the World Health Organization Asian criteria. RESULTS: The hazard ratio (diabetes v. not) for cardiovascular disease was 1.83 (95% confidence interval, 1.66-2.01). Across body mass index categories, this hazard ratio did not change significantly (p=0.19). Similar lack of difference across body mass index groups was found for coronary heart disease (p=0.33), ischemic stroke (p=0.97) and hemorrhagic stroke (p=0.98). CONCLUSIONS: Body mass index does not modify the effect of diabetes on major cardiovascular outcomes.

Original publication




Journal article


Prev Med

Publication Date





38 - 41


Adult Aged Australia *Body Mass Index Cohort Studies Coronary Disease/*etiology *Diabetes Mellitus Far East Female Humans Male Middle Aged New Zealand Proportional Hazards Models Risk Assessment Stroke/*etiology