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Tumor-infiltrating immune cells play important roles in metastasis. We have recently revealed the recruitment of a specific myeloid cell subset (CD11b/Gr1(mid)) to hepatic metastases. Such a recruitment relies on CCL2/CCR2 signaling and acts to sustain metastatic growth. A similar cell subset was identified in patients bearing hepatic metastases of colorectal cancer, highlighting the potential therapeutic relevance of our findings.

Original publication

DOI

10.4161/onci.23187

Type

Journal article

Journal

Oncoimmunology

Publication Date

01/03/2013

Volume

2

Keywords

CCL2, colon cancer, liver metastasis, myeloid cell recruitment