Recruitment of myeloid cells to the tumor microenvironment supports liver metastasis.
Lim SY., Gordon-Weeks AN., Zhao L., Tapmeier TT., Im JH., Cao Y., Beech J., Allen D., Smart S., Muschel RJ.
Tumor-infiltrating immune cells play important roles in metastasis. We have recently revealed the recruitment of a specific myeloid cell subset (CD11b/Gr1(mid)) to hepatic metastases. Such a recruitment relies on CCL2/CCR2 signaling and acts to sustain metastatic growth. A similar cell subset was identified in patients bearing hepatic metastases of colorectal cancer, highlighting the potential therapeutic relevance of our findings.