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Preeclampsia remains a significant obstetric risk worldwide. The pathophysiology of preeclampsia is complex, with multiple stages involving maladaptations in both placental and maternal physiology. The placenta links the pre-clinical stage of impaired remodeling of the uterine vasculature, occurring in early pregnancy, to the later clinical stages characterised by the maternal syndrome of hypertension and proteinuria. This review focuses on some of the recent candidates for the missing links in this process.

Original publication

DOI

10.1007/s11906-013-0395-7

Type

Journal article

Journal

Curr Hypertens Rep

Publication Date

12/2013

Volume

15

Pages

590 - 599

Keywords

Animals, Disease Models, Animal, Female, Humans, Hypertension, Placenta, Pre-Eclampsia, Pregnancy, Proteinuria