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Pre-eclampsia is a common and serious complication of pregnancy characterised by hypertension and proteinuria. Genetic and environmental factors influence the occurrence and progression of the disease. Emerging experimental systems and increasingly specific analytical methods for the study of differences between normal and pre-eclamptic placentae are close to identifying specific indicators of disease, which may allow early diagnosis and intervention and reveal targets against which therapeutic agents can be developed.

Original publication




Journal article


Expert Opin Ther Targets

Publication Date





507 - 514


Adult, Animals, Blood Proteins, Case Management, Cell Fractionation, Computational Biology, Cyclin-Dependent Kinase Inhibitor p57, Female, Gene Expression Profiling, Genetic Predisposition to Disease, Humans, Hypertension, Insulin-Like Growth Factor II, Ischemia, Mice, Mice, Knockout, Mice, Mutant Strains, Mice, Transgenic, Nuclear Proteins, Placenta, Pre-Eclampsia, Pregnancy, Proteomics, Renin-Angiotensin System, Risk Factors, Vasoconstriction