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OBJECTIVES: Compare the surgical morbidity of diaphragmatic peritonectomy versus full thickness diaphragmatic resection with pleurectomy at radical debulking. DESIGN: Prospective cohort study at the Oxford University Hospital. METHODS: All debulking with diaphragmatic peritonectomy and/or full thickness resection with pleurectomy in the period from April 2009 to March 2012 were part of the study. Analysis is focused on the intra- and postoperative morbidity. RESULTS: 42 patients were eligible for the study, 21 underwent diaphragmatic peritonectomy (DP, group 1) and 21 diaphragmatic full thickness resection (DR, group 2). Forty patients out of 42 (93%) had complete tumour resection with no residual disease. Histology confirmed the presence of cancer in diaphragmatic peritoneum of 19 patients out of 21 in group 1 and all 21 patients of group 2. Overall complications rate was 19% in group 1 versus 33% in group 2. Pleural effusion rate was 9.5% versus 14.5% and pneumothorax rate was 14.5% only in group 2. Two patients in each group required postoperative chest drains (9.5%). CONCLUSIONS: Diaphragmatic surgery is an effective methods to treat carcinomatosis of the diaphragm. Patients in the pleurectomy group experienced pneumothorax and a higher rate of pleural effusion, but none had long-term morbidity or additional surgical interventions.

Original publication

DOI

10.1155/2013/876150

Type

Journal article

Journal

Int J Surg Oncol

Publication Date

2013

Volume

2013

Keywords

Diaphragm, Female, Gynecologic Surgical Procedures, Humans, Middle Aged, Ovarian Neoplasms, Peritoneum, Pleura, Prospective Studies, Treatment Outcome