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Vitamin D receptor (VDR) gene polymorphisms may be associated with risk of developing type 1 diabetes mellitus (T1DM), but reports have been conflicting. The authors reexamined population-based case-control studies on selected VDR polymorphisms and T1DM to investigate whether variation in reported associations could be partly explained by differences in ambient winter ultraviolet radiation (UVR) levels. A meta-analysis of 16 studies from 19 regions (midwinter UVR range, 1.0-133.8 mW/m(2)) was conducted. The association between winter UVR and the log odds ratio was examined by meta-regression. For FokI and BsmI, the log odds ratio for the association between the F and B alleles and T1DM increased as regional winter UVR increased (p = 0.039 and p = 0.036, respectively). The association between the TaqI T allele and T1DM was reduced with increasing winter UVR (p = 0.040). Low winter regional UVR was associated with a higher proportion of controls carrying BsmI and ApaI uppercase alleles and a lower proportion of controls carrying TaqI uppercase alleles. These findings strengthen the case that VDR variants are involved in the etiology of T1DM. They suggest that environmental UVR may influence the association between VDR genotype and T1DM risk. Further work on VDR polymorphisms and T1DM should concomitantly examine the roles of past UVR exposure and vitamin D status.

Original publication

DOI

10.1093/aje/kwn142

Type

Journal article

Journal

Am J Epidemiol

Publication Date

15/08/2008

Volume

168

Pages

358 - 365

Keywords

Case-Control Studies, Deoxyribonucleases, Type II Site-Specific, Diabetes Mellitus, Type 1, Environmental Exposure, Gene Frequency, Genetics, Population, Genotype, Geography, Humans, Linkage Disequilibrium, Odds Ratio, Polymorphism, Restriction Fragment Length, Prevalence, Receptors, Calcitriol, Regression Analysis, Risk Factors, Seasons, Ultraviolet Rays, Vitamin D Deficiency