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Multiple sclerosis (MS) is a chronic autoimmune disorder that causes inflammatory demyelination and axonal damage in the central nervous system (CNS). We have investigated whether the A49G single nucleotide polymorphism (SNP) genotype of the CTLA-4 gene influenced the development of MS in Southern Australians as well as the interaction of this SNP with the DRB1*15 haplotype. There were no significant (P<0.05) associations between the A49G genotype and risk of MS, either before or after stratification for presence of the DR15 haplotype.

Original publication

DOI

10.1016/j.jneuroim.2008.02.001

Type

Journal article

Journal

J Neuroimmunol

Publication Date

30/05/2008

Volume

196

Pages

139 - 142

Keywords

Antigens, CD, Australia, CTLA-4 Antigen, Gene Frequency, Genetic Predisposition to Disease, Genotype, HLA-DR Antigens, Humans, Multiple Sclerosis, Polymorphism, Single Nucleotide