Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

OBJECTIVES: To assess the economic impact of introducing the soluble FMS-like tyrosine kinase (sFlt-1) to placental growth factor (PlGF) ratio test into clinical practice in the United Kingdom (UK). METHODS: Economic model estimating the incremental value of the information from a UK National Health Service (NHS) payer perspective generated by the sFlt-1/PlGF ratio test, compared with current diagnostic procedures, in guiding the management of women with suspected pre-eclampsia. The economic model estimated costs associated with the diagnosis and management of pre-eclampsia in women between 24 weeks and 36 weeks + 6 days of gestation managed in either a 'test' scenario in which the sFlt-1/PlGF test is used in addition to current diagnostic procedures, or a 'no-test' scenario in which clinical decisions are based on current diagnostic procedures alone. Test characteristics and resource use were derived from PROGNOSIS, a non-interventional study in women presenting with clinical suspicion of pre-eclampsia. The main outcome measure from the economic model was the cost per patient per episode of care (from first suspicion of pre-eclampsia to birth). RESULTS: Introduction of the sFlt-1/PlGF ratio test is expected to result in cost savings of £344 per patient compared with a 'no-test' scenario. Savings are generated primarily through an improvement in diagnostic accuracy and a reduction in unnecessary hospitalisation. CONCLUSIONS: The sFlt-1/PlGF ratio test has the potential to improve clinical decision-making, reducing unnecessary hospitalisation of women at low risk of developing pre-eclampsia, and ensuring that those women at higher risk are identified and managed appropriately.

Original publication




Journal article


Ultrasound Obstet Gynecol

Publication Date



Cost-effectiveness, Diagnosis, Economic, Hospitalization, Model, Pre-eclampsia, Prediction, sFlt-1/PlGF