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We have analyzed the in vitro activities of pyronaridine and methylene blue against 59 Plasmodium falciparum isolates from Kenya in association with polymorphisms in Pfcrt (codon 76), Pfmdr1 (codon 86), and Pfnhe (full sequence). The median inhibitory concentrations that kill 50% of parasites were 13.5 and 3.3 nM for pyronaridine and methylene blue, respectively. Their activities were not associated with polymorphisms in these genes. The drugs' high in vitro activities indicate that they would be efficacious against Kenyan isolates in vivo.

Original publication

DOI

10.1128/AAC.05454-11

Type

Journal article

Journal

Antimicrob Agents Chemother

Publication Date

02/2012

Volume

56

Pages

1105 - 1107

Keywords

Animals, Antimalarials, Humans, Kenya, Malaria, Falciparum, Methylene Blue, Naphthyridines, Parasitic Sensitivity Tests, Plasmodium falciparum, Polymorphism, Genetic, Protozoan Proteins