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Preeclampsia (PE) is disorder of new onset hypertension and proteinuria during the second half of pregnancy. There is increasing evidence to implicate placental over-expression of tissue factor and PAR-1 in the pathophysiology of PE. Excessive activation of platelets, neutrophils and the complement system may also contribute to the placental pathology and maternal endothelial responsible for the symptoms of PE. Increased knowledge in this field may identify new therapeutic strategies for the treatment of PE.

Original publication

DOI

10.1016/S0049-3848(17)30067-1

Type

Journal article

Journal

Thromb Res

Publication Date

03/2017

Volume

151 Suppl 1

Pages

S48 - S52

Keywords

Haemostasis, Platelets, Preeclampsia, Syncytiotrophoblast, Tissue factor, Antibodies, Antiphospholipid, Blood Platelets, Complement Activation, Female, Hemostasis, Humans, Neutrophils, Placenta, Platelet Activation, Pre-Eclampsia, Pregnancy, Thromboplastin, Trophoblasts