Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Successful placentation in the human is dependent on the trophoblast evading recognition and destruction by the maternal immune system. However, invasive cytotrophoblast express HLA-G which may be able to present peptide to T cells. Transporter proteins are essential for peptide presentation and major histocompatibility complex (MHC) class I assembly. We have determined their expression by trophoblast in relation to HLA-G, using immunohistochemistry. Anti-transporter protein antibody (TAP1) labeling closely paralleled that of MHC class I, but the intensity of its expression was much greater on the HLA-G+ extravillous cytotrophoblast than any other fetal or maternal tissue in the first trimester and at term. This suggests that the extravillous cytotrophoblast are very actively assembling MHC class I antigens with peptides. However, expression of MHC class I by the cytotrophoblast was not correspondingly elevated. This pattern could result from HLA-G being shed from the surface of the trophoblast, a process which may play a central role in protecting the fetus from maternal immune attack.

Original publication

DOI

10.1002/eji.1830250236

Type

Journal article

Journal

Eur J Immunol

Publication Date

02/1995

Volume

25

Pages

543 - 553

Keywords

ATP-Binding Cassette Transporters, Animals, Antigen Peptide Transporter-1, Female, HLA Antigens, HLA-G Antigens, Histocompatibility Antigens Class I, Humans, Immunohistochemistry, Mice, Pregnancy, Pregnancy Trimester, First, RNA, Messenger, Trophoblasts