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Preeclampsia is a multisystem hypertensive disorder of pregnancy and is one of the largest causes of maternal and fetal mortality and morbidity worldwide.

Placental microvesicles and exosomes in preeclampsia

Preeclampsia is a multisystem hypertensive disorder of pregnancy and is one of the largest causes of maternal and fetal mortality and morbidity worldwide.  The disease is caused by the placenta - since the disease can occur in trophoblast tumours (in the absence of the fetus) and delivery remains the only cure for the disease.  We know that the placenta constitutively sheds  microvesicles and exosomes into the maternal circulation and we have recently conducted a large scale mass spectrometric and deep sequencing analysis of these vesicles. The data have ben bioinformatically processed and the data is now ready for exploitation. This project would see the successful candidate take forward three marers (protein, mRNA and miRNA) for characterization and functional analysis. 

Training opportunities

The project represents an opportunity to be fully trained in extracellular vesicle extraction, processing, characterization and downstream functional assessment.  Standard molecular biology techniques are well established in the group and active collaborations exist with groups all over the world providing opportunities for travel.    

Supervisor

Dr Manu Vatish