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- Endometrial immune cells and their role in sub-fertility and recurrent miscarriage
- The interactions seminal fluid extracellular vesicles and endometrial cells
- Embryo factors that enhance implantation
- The influence of follicular fluids on oocyte viability
- Cytokines in pathological pregnancies, in particular IL-33 and its decoy sST2 which we have shown is highly elevated in pre-eclampsia
- Understanding the impact of pregnancy on long-term health
- Miscarriage Research Topics
DPhil MA MBBS MRCOG
Senior Research Fellow in Reproductive Medicine
- Principal Investigator
- Research Group Leader
- Honorary Consultant Gynaecologist and Sub-Specialist in Reproductive Medicine and Surgery
- Consultant in Reproductive Medicine at Oxford Fertility Unit
- Lead for Recurrent Miscarriage and Early Pregnancy at Oxford University Hospitals NHS Trust
I graduated from the Royal Free Hospital School of Medicine, University of London in 1998. I undertook my early training in the North-West Deanery before leaving for Sydney to work. I returned to the Oxford Deanery Training Programme in 2003. During this time I undertook a MA in Medical Law and Ethics and a DPhil (with Professor Ian Sargent) in Reproductive Immunology. I was appointed as an NIHR Academic Clinical Lecturer in 2012 whilst also undertaking sub-specialty training in Reproductive Medicine. I was appointed as a Senior Clinical Fellow and Consultant Gynaecologist in 2014
The OxWATCH study
The aim of this study is to understand the impact of a first pregnancy (normal or complicated) on the long-term health of women. To do this we are recruiting women before their first successful pregnancy, following them in pregnancy and in the early post-natal period. We are currently in the pilot phase of the study. Further information on the study and how take part can be found at: http://www.osprea.ox.ac.uk/oxwatch/
Association of Maternal Antiangiogenic Profile at Birth With Early Postnatal Loss of Microvascular Density in Offspring of Hypertensive Pregnancies.
Yu GZ. et al, (2016), Hypertension, 68, 749 - 759
Endometrial Tissue Resident Memory T Cells.
Southcombe J. et al, (2016), REPRODUCTIVE SCIENCES, 23, 69A - 69A
Characterization of NK Cells in Endometriosis Associated Pain.
Soderstrom K. et al, (2016), REPRODUCTIVE SCIENCES, 23, 161A - 161A
Oxfordshire Women and Their Children's Health (OxWATCH): protocol for a prospective cohort feasibility study.
Harrison S. et al, (2015), BMJ Open, 5
Interleukin-1 family cytokines and their regulatory proteins in normal pregnancy and pre-eclampsia.
Southcombe JH. et al, (2015), Clin Exp Immunol, 181, 480 - 490