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PhD Bath University (1990)
Post Doctoral Positions (1990-2009)
Bristol University, Oxford University & The Buck Institute
for Research on Aging
Consultancy & Committees
London Technology Business Fellow (2006-2010)
Oxford Metabolism Committee (2014-)
Current Research Funding
Williams Fund, ME association UK
Michelle Potter (Post Doctoral Researcher)
Emma Newport (Placement Student)
Enquiries from prospective PhD students are always welcome
In addition to my laboratory manager role I run an active research group with a focus on understanding the role of mitochondria in health and disease.
Current projects include (i) targeting energy metabolism as a therapeutic strategy in cancer and (ii) establishing protocols to assess mitochondrial function in neutrophils and monocytes.
Research allows you to develop exciting collaborations with a wide range of people from different disciplines. Establishing collaborative research projects is one of my major passions and I am always interested in discussing exciting new projects.
Individuals interested in research in any of the areas above or below are welcome to contact me.
MitOX meeting. December 6th 2016, John Radcliffe Hospital. This in an annual meeting which brings together mitochondrial enthusiasts from Oxford and the South East. Currently in it's eighth year MitOX is very popular with over 170 delegates attending last year.
Collaborations within NDOG.
Professor Joanna Poulton: Investigating the pathogenesis and treatment strategies in patients with mitochondrial disease. Two research grants are currently active: (i) Investigating the biology of mitochondrial DNA disease transmission to enable affected families to have healthy children (MRC) and (ii) Developing treatments for mtDNA diseases (Welcome Trust). Joanna and I have worked together on a wide range of projects for over 20 years
Dr Helen Townley: Nanotherapeutic delivery of anti-cancer therapeutics. Project supported by Williams fund. Helen and I work closely developing novel nanoparticle drug combinations which can target cancer cell metabolism. Helen is part of NDOG and runs a laboratory at the Begbroke Science Park.
Dr Joris Hemelaar & Dr Michelle Fernandes: The impact of mitochondrial associated drug toxicity in foetal development. This is a new project idea and is still at the drawing board stage deciding which drugs used in pregnancy we should test in our in vitro models
Professor Christian Becker & Professor Krina Zondervan: Therapeutic strategies in Endometriosis. Project supported by Bayer. This is an exciting project just about to start investigating new therapeutic targets and treatment strategies in Endometriosis.
Monitoring Intracellular Oxygen Concentration: Implications for Hypoxia Studies and Real-Time Oxygen Monitoring.
Morten K. et al, Advances in Experimental Biology
Dysregulated mitophagy and mitochondrial organization in optic atrophy due to OPA1 mutations.
Liao C. et al, (2017), Neurology, 88, 131 - 142
Correction: Is Placental Mitochondrial Function a Regulator that Matches Fetal and Placental Growth to Maternal Nutrient Intake in the Mouse?
Chiaratti MR. et al, (2017), PLoS One, 12
Modulating mitochondrial quality in disease transmission: towards enabling mitochondrial DNA disease carriers to have healthy children.
Diot A. et al, (2016), Biochem Soc Trans, 44, 1091 - 1100
Mitophagy plays a central role in mitochondrial ageing.
Diot A. et al, (2016), Mamm Genome, 27, 381 - 395
Using an Integrated -Omics Approach to Identify Key Cellular Processes That Are Disturbed in the Kidney After Brain Death
Akhtar MZ. et al, (2016), American Journal of Transplantation, 16, 1421 - 1440
Collaborations within Oxford.
Dr Leanne Hodson (OCDEM), Dr Charlotte Green and Mr Mike Silva (NDS). Development and validation of a human hepatocyte model to investigate how liver fat metabolism influences metabolic disease. This work involves using isolate human hepatocytes and a human liver stem cell to study a variety of disease processes in the liver.
Dr Brad Sutherland (RDM). Development of in vitro embryonic neuronal models to assess foetal drug toxicity. This is a pilot project with Mrs Tiffany Lodge investigating the effect of the anti-epileptic drug Sodium Valproate on foetal neuronal development.
Professor Peter Friend (NDS) & Mr David Nassralla. This study investigates protective role of normothermic recirculation in preventing ischaemia reperfusion injury in human liver. Our current hypothesis is that ischaemia associated liver graft failure is linked to mitochondrial dysfunction and failed bioenergetics. In the future this collaboration will be investigating samples from the Consortium for Organ Preservation Europe trial.
Dr Steve Sheard (Eng), Professor Ian Sargent & Dr Rebecca Dragovic (NDOG). Continuous separation of cellular micro and nanovesicles for the early detection of pre-eclampsia and use as cancer biomarkers.
National and International Collaborators
Professor Jeung Sang Go (Pussan National University, South Korea). Various microfluidic projects including i) Continual synthesis of protein loaded nanoparticles ii) microvesicle separation and iii) 3D perfusion models for continual cell culture.