DR MANU VATISH
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|Fax||+44 (0)1865 769141|
2008 Fulbright Distinguished Scholar Award
2011 Churchill Fellowship
Wei Zhang - Postdoctoral Research Scientist
Gavin Collett - Postdoctoral Research Scientist
Sofia Cerdeira - Postdoctoral Clinical Fellow
Vuyane Mhlomi - DPhil Student & Rhodes Scholar
Neva Kandzija - Technician - commencing DPhil in October 2016
Alexandra Burdujan - placement student
Sylvia Shahjahan - Technician - now reading medicine at Imperial
2014- Research Grant - Silence Therapeutics
2014 - Research Grant - Roche Diagnostics
2006-2016 - Programme Grant MRC ( 2 yr extension)
Group Photo 2015
Opportunities to work with us
We are always keen to hear from people interested in working or studying with us (e.g., potential DPhil, MSc by Research, ERASMUS students, summer students, postdocs). Please contact Dr Vatish by email in the first instance.
There are a number of scholarships that high-calibre candidates can apply for within the University of Oxford as well as the European Union.
MBBCh BA(Hons) DPhil MA(Cantab) MRCOG
Senior Clinical Fellow in Obstetrics
- Principal Investigator
- Research Group Leader
- Grant Holding Senior Scientist
- Clinical Consultant in Obstetrics
- NIHR CRN National Specialty Lead for Reproductive Health (Thames Valley & South Midlands)
- Research Advisory Committee Member - Wellbeing of Women
I undertook preclinical medicine at Keble College, Oxford followed by a DPhil at Brasenose College (under the aegis of Dr. Richard Boyd) and I completed clinical training at Cambridge (Queens’ College). Specialist training in obstetrics & gynaecology on the Oxford training rotation was followed by a clinical lectureship at Warwick and senior lectureship/consultant at Warwick. Fulbright and Churchill Fellowships (in New York & Yale) preceded a move back to Oxford in 2013 as Senior Clinical Fellow/Consultant in Obstetrics.
Pregnancy is generally a time of great happiness and expectation and yet a significant number of pregnancies are affected by diseases such as gestational diabetes and preeclampsia. These diseases cause significant short and long term problems for both the mother and her baby. It is clear that the placenta, the organ responsible for orchestrating the transfer of nutrients and oxygen from the mother to the fetus, is responsible for these diseases since delivery of the baby (and therefore the placenta) cures the diseases. My research focuses on the hormonal signaling between the placenta and the mother and the mechanisms by this signaling can be disrupted in disease. These studies are basic science in nature, but there also clinical studies being undertaken examining the use of circulating placental biomarkers in managing patients with preeclampsia. More recently, working together with Professors Redman & Sargent we have started to examine the role of placental microvesicles (small particles shed from the surface of the placenta into the maternal circulation) in insulin resistance - a common feature of preeclampsia and gestational diabetes.
I am a clinical academic and practicing obstetrician at the Oxford University Hospitals NHS Trust. I see patients in clinics as well as on the labour ward and take full part in the on call rota for acute obstetrics at the John Radcliffe Hospital.
Additionally, I am NIHR CRN lead for Division 3 (haematology, genetics, paediatrics and reproductive health) for the Thames Valley and South Midlands providing CRN support for portfolio studies in these specialties.
I am also NIHR National Specialty Lead for Reproductive Health representing the Thames Valley & South Midlands.
Low vitamin B12 in pregnancy is associated with adipose derived circulating miRs targeting PPARγ and insulin resistance.
Adaikalakoteswari A. et al, (2017), J Clin Endocrinol Metab
Placental Vesicles Carry Active Endothelial Nitric Oxide Synthase and Their Activity is Reduced in Preeclampsia.
Motta-Mejia C. et al, (2017), Hypertension, 70, 372 - 381
Re: Screening for pre-eclampsia using sFlt-1/PlGF ratio cut-off of 38 at 30-37 weeks' gestation.
Vatish M. et al, (2017), Ultrasound Obstet Gynecol, 49, 665 - 666
Syncytiotrophoblast extracellular vesicles - Circulating biopsies reflecting placental health.
Tannetta D. et al, (2017), Placenta, 52, 134 - 138
Impact of haemostatic mechanisms on pathophysiology of preeclampsia.
Gardiner C. and Vatish M., (2017), Thromb Res, 151 Suppl 1, S48 - S52